Measurement of glomerular filtration rate using 99mTc-DTPA and the gamma camera: a comparison of methods

A variety of methods have been proposed to estimate the glomerular filtration rate (GFR) from the renal uptake of technetium Tc 99m-DTPA using a gamma camera. To compare alternative methods, we calculated the GFR in several different ways from measurements in 33 patients and compared the results wit...

Full description

Saved in:
Bibliographic Details
Published in:European Journal of Nuclear Medicine 1985, Vol.10 (11-12), p.519-521
Main Authors: RUSSELL, C. D, BISCHOFF, P. G, KONTZEN, F, ROWELL, K. L, YESTER, M. V, LLOYD, L. K, TAUXE, W. N, DUBOVSKY, E. V
Format: Article
Language:English
Subjects:
Biological and medical sciences
Glomerular Filtration Rate
Humans
Investigative techniques of renal and urinary tract function
Investigative techniques, diagnostic techniques (general aspects)
Kidney - diagnostic imaging
Medical sciences
Pentetic Acid
Radioisotopes
Radionuclide Imaging
Software
Technetium
Technetium Tc 99m Pentetate
Ytterbium
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A variety of methods have been proposed to estimate the glomerular filtration rate (GFR) from the renal uptake of technetium Tc 99m-DTPA using a gamma camera. To compare alternative methods, we calculated the GFR in several different ways from measurements in 33 patients and compared the results with an independent GFR measurement based on eight-point plasma clearance of ytterbium Yb 169-DTPA. The best agreement was obtained using an algorithm that has not been described previously, in which correction was made for overlap of the kidneys by the liver and spleen. The correlation coefficient was 0.958, and the residual standard deviation was 12.1 ml/min. This method required a single 20-min blood sample as well as the camera data. The best method not requiring a blood sample was significantly less accurate, with a correlation coefficient of 0.837 and a residual standard deviation of 23.1 ml/min. The accuracy of these methods was comparable to that reported for creatinine clearance, the most commonly used estimate of the GFR in current clinical practice.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00252744