The testis: a protected environment for leukaemic cells against cyclophosphamide in a mouse model

Groups of BDF1 mice, inoculated either IM or by the intratesticular (IT) route with comparable numbers of L1210 cells, died within the same time range from the disseminated disease. Cyclophosphamide (100 mg/kg IP) given on day 6 after inoculation, when the disease was advanced, increased the lifespa...

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Bibliographic Details
Published in:Cancer chemotherapy and pharmacology 1983, Vol.11 (3), p.200-202
Main Authors: JACKSON, H, BOCK, M, JACKSON, N. C, LENDON, M
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Chemotherapy
Cyclophosphamide - therapeutic use
Disease Models, Animal
Drug Resistance
Leukemia L1210 - drug therapy
Leukemia L1210 - mortality
Leukemia L1210 - physiopathology
Male
Medical sciences
Mice
Mice, Inbred Strains
Neoplasm Recurrence, Local
Pharmacology. Drug treatments
Testicular Neoplasms - drug therapy
Testicular Neoplasms - mortality
Testicular Neoplasms - physiopathology
Testis - ultrastructure
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Summary:Groups of BDF1 mice, inoculated either IM or by the intratesticular (IT) route with comparable numbers of L1210 cells, died within the same time range from the disseminated disease. Cyclophosphamide (100 mg/kg IP) given on day 6 after inoculation, when the disease was advanced, increased the lifespan by about 100%, but all the mice died. The same dose on day 3 effectively cured all mice inoculated IM, whereas those injected with cells into the testicular lymphatic sinusoidal system died with only a short prolongation of lifespan. The study indicates that L1210 cells present in the testis are relatively protected from the action of cyclophosphamide, and the experimental results are consistent with clinical evidence for the occurrence of relapse in children with ALL due to malignant lymphoblasts persisting in the testicular environment.
ISSN:0344-5704
1432-0843
DOI:10.1007/BF00254205