Gastrointestinal scintigraphy with 99mTc-DTPA labeled tablets in fed and fasting subjects

The in vitro and in vivo dissolution of a sustained release theophylline formulation labeled with 99mTc-diethyltriaminepentaacetic acid (DTPA) has been monitored in six subjects with a scintillation camera. The study was performed in fasting conditions and was repeated after ingestion of a standardi...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1989, Vol.15 (3), p.143-145
Main Authors: MAUBLANT, J. C, SOURNAC, M, AIACHE, J. M, VEYRE, A
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Delayed-Action Preparations
Digestion. Liver. Biliary tract. Spleen. Pancreas
Eating
Fasting
Gastrointestinal Transit
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Organometallic Compounds
Pentetic Acid
Radionuclide investigations
Tablets
Technetium
Technetium Tc 99m Pentetate
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Description
Summary:The in vitro and in vivo dissolution of a sustained release theophylline formulation labeled with 99mTc-diethyltriaminepentaacetic acid (DTPA) has been monitored in six subjects with a scintillation camera. The study was performed in fasting conditions and was repeated after ingestion of a standardized meal. Results showed that the presence of food in the stomach dramatically increased the oesoduodenal transit time of the tablet (74 +/- 27 min vs 352 +/- 77 min, P less than 0.001) but did not modify the biodisponibility of theophylline. This study is another example when scintigraphy can be of definite value in pharmacokinetics.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00254627