Keyhole-limpet haemocyanin (KLH) immunotherapy of murine transitional cell carcinoma

The antigenicity of transitional cell carcinoma of the bladder has stimulated the search for effective immunotherapeutic agents in the treatment of this disease. Non-specific immunotherapy with local (intravesical/intralesional) and systemic Keyhole Limpet Haemocyanin (KLH) in a FANFT induced murine...

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Bibliographic Details
Published in:Urological research 1983, Vol.11 (6), p.263-265
Main Authors: Walsh, W G, Tomashefsky, P, Olsson, C A, deVere White, R
Format: Article
Language:English
Subjects:
Animals
Antigens - administration & dosage
Antigens - therapeutic use
Carcinoma, Transitional Cell - chemically induced
Carcinoma, Transitional Cell - immunology
Carcinoma, Transitional Cell - therapy
FANFT
Female
Hemocyanins
Injections, Subcutaneous
Mice
Mice, Inbred C3H
Urinary Bladder Neoplasms - chemically induced
Urinary Bladder Neoplasms - immunology
Urinary Bladder Neoplasms - therapy
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Summary:The antigenicity of transitional cell carcinoma of the bladder has stimulated the search for effective immunotherapeutic agents in the treatment of this disease. Non-specific immunotherapy with local (intravesical/intralesional) and systemic Keyhole Limpet Haemocyanin (KLH) in a FANFT induced murine bladder tumor model was studied. Results showed no difference between control or treated groups in either tumor growth or animal survival.
ISSN:0300-5623
1434-0879
DOI:10.1007/BF00256343