The stability and distribution of Tc-HIDA in vivo and in vitro

Tc-HIDA is a promising new agent for imaging the biliary system. In this study radiochromatography on paper or Sephadex G25 gel has been used to measure the proportions of TcHIDA, 'hydrolysed Tc' and pertechnetate in solutions from a commercial kit (CIS TCK 15) and in body fluids from pati...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1979-10, Vol.4 (5), p.369-373
Main Authors: Zivanovic, M A, Taylor, D M, McCready, V R, Meller, S T
Format: Article
Language:English
Subjects:
Animals
Drug Stability
Female
Humans
Imino Acids - metabolism
In Vitro Techniques
Liver - diagnostic imaging
Male
Radionuclide Imaging
Rats
Technetium - metabolism
Tissue Distribution
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Summary:Tc-HIDA is a promising new agent for imaging the biliary system. In this study radiochromatography on paper or Sephadex G25 gel has been used to measure the proportions of TcHIDA, 'hydrolysed Tc' and pertechnetate in solutions from a commercial kit (CIS TCK 15) and in body fluids from patients and rats receiving this radiopharmaceutical. The tissue distribution in male and female rats has shown the radiopharmaceutical to be rapidly removed from the blood by the liver and then excreted via the intestines. There appears to be a sex difference in the uptake in the kidneys and in the urinary excretion in both rats and patients.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00263306