Inactivation of cis-diamminedichloroplatinum (II) in blood and protection of its toxicity by sodium thiosulfate in rabbits

The mode of inactivation of cis-diamminedichloroplatinum(II) (DDP) in the bloodstream and protection from its toxicity by sodium thiosulfate (STS) were investigated in rabbits. Plasma ultrafiltrate in rabbits given 5 mg/kg DDP IV and various excess molar ratios of STS IV were assayed for the active...

Full description

Saved in:
Bibliographic Details
Published in:Cancer chemotherapy and pharmacology 1985-10, Vol.15 (3), p.228-232
Main Authors: IWAMOTO, Y, KAWANO, T, ISHIZAWA, M, AOKI, K, KUROIWA, T, BABA, T
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Cisplatin - blood
Cisplatin - pharmacology
Cisplatin - toxicity
Drug Interactions
Escherichia coli - drug effects
Female
General aspects
Kinetics
Medical sciences
Pharmacology. Drug treatments
Rabbits
Spectrophotometry, Atomic
Thiosulfates - pharmacology
Ultrafiltration
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The mode of inactivation of cis-diamminedichloroplatinum(II) (DDP) in the bloodstream and protection from its toxicity by sodium thiosulfate (STS) were investigated in rabbits. Plasma ultrafiltrate in rabbits given 5 mg/kg DDP IV and various excess molar ratios of STS IV were assayed for the active platinum levels with a new microbiological assay system using an E. coli strain. The active platinum species in the plasma were inactivated completely by co-administration of a 400-fold excess of STS IV. The rabbits were almost completely protected against both BUN increase and body weight loss normally caused by DDP when 400-fold doses of STS were given. Diuretic effects were also observed. Our data provide evidence for the basis of optimum use of STS to protect against DDP toxicity.
ISSN:0344-5704
1432-0843
DOI:10.1007/bf00263891