Radionuclide imaging of Meckel's diverticulum: cimetidine versus pentagastrin plus glucagon

The aim of this study was to investigate the effects of prior administration of cimetidine in radionuclide imaging of Meckel's diverticulum. In three groups of seven rats with artificial Meckel's diverticulum, containing ectopic gastric mucosa, the effects of pentagastrin + glucagon plus 9...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1984-07, Vol.9 (7), p.316-319
Main Authors: YEKER, D, BÜYÜKÜNAL, C, BENLI, M, BÜYÜKÜNAL, E, URGAN CIOGLU, I
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cimetidine - administration & dosage
Gastric Mucosa - metabolism
Gastroenterology. Liver. Pancreas. Abdomen
Glucagon - administration & dosage
Humans
Male
Meckel Diverticulum - diagnostic imaging
Meckel Diverticulum - metabolism
Medical sciences
Methods
Other diseases. Semiology
Pentagastrin - administration & dosage
Radionuclide Imaging
Rats
Rats, Inbred Strains
Sodium Pertechnetate Tc 99m
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Technetium - metabolism
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Summary:The aim of this study was to investigate the effects of prior administration of cimetidine in radionuclide imaging of Meckel's diverticulum. In three groups of seven rats with artificial Meckel's diverticulum, containing ectopic gastric mucosa, the effects of pentagastrin + glucagon plus 99mTc-pertechnetate, as well as cimetidine premedication plus 99mTc-pertechnetate, and 99mTc-pertechnetate alone were compared to attain improved radionuclide imaging of Meckel's diverticulum. This experimental model suggests that the use of cimetidine seemed to have some advantages: (a) nontarget (intestinal) radioactivity was diminished by cimetidine, (b) the target to nontarget (Meckel's diverticulum to intestinal activity) ratio increased with cimetidine pretreatment. This resulted in an enhanced accumulation of pertechnetate in the ectopic gastric mucosa, and reduced excretion of the radionuclide into the lumen. Consequently, better scintiphotograms and a low rate of false results added to the validity of this method.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00276461