Long-term haemodynamic effects of sustained-release trimazosin at rest and during exercise in essential hypertension

The long-term haemodynamic effect of sustained-release trimazosin (mean daily dose 418 mg) at rest and during exercise has been examined in 14 male patients (age 30-61 y) with previously untreated mild or moderate essential hypertension. Cardiac output (dye dilution), heart rate and intra-arterial b...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1991-02, Vol.40 (2), p.131-134
Main Authors: OMVIK, P, LUND-JOHANSEN, P
Format: Article
Language:English
Subjects:
Adult
Antihypertensive agents
Antihypertensive Agents - administration & dosage
Antihypertensive Agents - adverse effects
Biological and medical sciences
Cardiovascular system
Delayed-Action Preparations
Exercise - physiology
Hemodynamics - drug effects
Humans
Hypertension - drug therapy
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Piperazines - administration & dosage
Piperazines - adverse effects
Rest - physiology
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Summary:The long-term haemodynamic effect of sustained-release trimazosin (mean daily dose 418 mg) at rest and during exercise has been examined in 14 male patients (age 30-61 y) with previously untreated mild or moderate essential hypertension. Cardiac output (dye dilution), heart rate and intra-arterial blood pressure were measured supine and sitting at rest, and during bicycle exercise. After 11 months of trimazosin treatment the mean casual blood pressure was reduced from 165/106 mmHg to 147/92 mmHg. The intra-arterial systolic and diastolic pressure was reduced by 3-7% at rest and during 50, 100 and 150 W exercise. Total peripheral resistance was reduced by 8-14% and cardiac output was slightly higher (2-8%) in all situations. Stroke volume and heart rate remained unchanged, as did body fluid volumes (isotope dilution) and body weight. Side effects were minor and transient. Thus, the haemodynamic responses to trimazosin are similar to but weaker than those of other alpha 1-adrenoceptor blockers. The efficacy of the sustained-release formulation of trimazosin was low and daily doses above 600 mg are likely to be needed by many patients.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00280066