Myocardial uptake of thallium-201 diethyldithiocarbamate (201Tl-DDC) in cultured heart cells and in humans

We assessed the feasibility of SPECT imaging with 201T1-diethyldithiocarbamate (201T1-DDC), a new cerebral blood flow tracer with little distribution, expecting to observe less extensive redistribution than with 201T1-chloride. Myocardial sections were obtained in three patients presenting with docu...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1987-11, Vol.13 (8), p.408-409
Main Authors: MAUBLANT, J. C, MOINS, N, VAN ROYEN, E. A, LUSSON, J.-R, CASSAGNES, J, VEYRE, A, GACHON, P
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiovascular system
Cells, Cultured
Coronary Disease - diagnostic imaging
Ditiocarb
Heart - diagnostic imaging
Humans
In Vitro Techniques
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Middle Aged
Radionuclide investigations
Rats
Thallium Radioisotopes
Tissue Distribution
Tomography, Emission-Computed
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Summary:We assessed the feasibility of SPECT imaging with 201T1-diethyldithiocarbamate (201T1-DDC), a new cerebral blood flow tracer with little distribution, expecting to observe less extensive redistribution than with 201T1-chloride. Myocardial sections were obtained in three patients presenting with documented coronary artery disease and injected at peak exercise with 100 MBq 201T1-DDC. In two patients there was a clear redistribution phenomenon at four h after injection. In cultured myocardial cells of newborn rats, the uptake and washout of 201T1-chloride and 201T1-DDC were compared. The 201T1-DDC uptake was lower than 201T1-chloride (transmembrane gradients were respectively 89 +/- 10 and 4.1 +/- 0.2, mean +/- sem, n = 14, P less than 0.001). After 2 h washout in a T1 free medium, the retention of 201T1-chloride in the cells was 4% vs 19% for 201T1-DDC. It is concluded that although myocardial imaging is feasible with 201T1-DDC, this agent redistributes significantly with time.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00292493