Inhibition of salicylate and lithium absorption in the human intestine by copper sulfate

Copper sulfate, given orally in an emetic dose, decreased the absorption of therapeutic doses of acetylsalicylic acid or lithium carbonate, more than was expected judging from the recovery of salicylic acid in the vomit. Ten volunteers participated.

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Bibliographic Details
Published in:Archives of toxicology 1976-06, Vol.35 (3), p.175-179
Main Authors: Lindkaer-Jensen, S, Nellemann-Sorensen, P
Format: Article
Language:English
Subjects:
Adult
Aspirin - metabolism
Aspirin - poisoning
Copper - pharmacology
Copper - therapeutic use
Emetics - therapeutic use
Humans
Intestinal Absorption - drug effects
Lithium - metabolism
Lithium - poisoning
Poisoning - drug therapy
Sulfates - therapeutic use
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Description
Summary:Copper sulfate, given orally in an emetic dose, decreased the absorption of therapeutic doses of acetylsalicylic acid or lithium carbonate, more than was expected judging from the recovery of salicylic acid in the vomit. Ten volunteers participated.
ISSN:0340-5761
1432-0738
DOI:10.1007/BF00293564