Flavone acetic acid (LM 975, NSC 347512): a novel antitumor agent

Flavone acetic acid (FAA) is a synthetic flavonoid compound which has recently begun clinical trials as an antitumor agent based on its striking activity in solid tumor model systems. The pharmacologic behavior of FAA in animals appears to be predictive of both its cytotoxic efficacy and its toxicit...

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Bibliographic Details
Published in:Cancer chemotherapy and pharmacology 1987-01, Vol.19 (1), p.6-10
Main Authors: O'DWYER, P. J, SHOEMAKER, D, LEYLAND-JONES, ZAHARKO, D. S, GRIESHABER, C, PLOWMAN, J, CORBETT, T, VALERIOTE, F, KING, S. A, CRADOCK, J, HOTH, D. F
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Antineoplastic Agents - toxicity
Biological and medical sciences
Dogs
Drug Evaluation
Drug Evaluation, Preclinical
Flavonoids - pharmacology
Flavonoids - therapeutic use
Flavonoids - toxicity
General aspects
Humans
Kinetics
Medical sciences
Mice
Neoplasms, Experimental - drug therapy
Pharmacology. Drug treatments
Rats
Structure-Activity Relationship
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Summary:Flavone acetic acid (FAA) is a synthetic flavonoid compound which has recently begun clinical trials as an antitumor agent based on its striking activity in solid tumor model systems. The pharmacologic behavior of FAA in animals appears to be predictive of both its cytotoxic efficacy and its toxicity to normal tissues (principally the central nervous system and gastrointestinal tract). The design and conduct of phase I studies in man are based upon these principles, with the goal of maximizing their safety and efficacy.
ISSN:0344-5704
1432-0843
DOI:10.1007/BF00296246