Interaction between glucose diet and ethanol on rat liver microsomal induction and liver plasma membrane damage in chronic hexachlorobenzene intoxication

Male Wistar rats fed for 60 days a glucose diet containing 17.5 mmol hexachlorobenzene/kg show a less pronounced increase in serum parameters and microsomal cytochrome P-450 concentration and a lower decrease in liver plasma membrane 5'-nucleotidase, K+, Na+- and Mg++-adenosine triphosphatase a...

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Bibliographic Details
Published in:Archives of toxicology 1987-05, Vol.60 (1-3), p.112-114
Main Authors: NIKOLAEV, V, NAYDENOVA, E, KERIMOVA, M, DIMOV, S, IVANOV, E, TCHERNEV, K
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Membrane - drug effects
Chlorobenzenes - toxicity
Dietary Carbohydrates - pharmacology
Enzyme Induction - drug effects
Ethanol - pharmacology
Glucose - pharmacology
Hexachlorobenzene - toxicity
Male
Medical sciences
Microsomes, Liver - enzymology
Pesticides, fertilizers and other agrochemicals toxicology
Rats
Rats, Inbred Strains
Toxicology
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Summary:Male Wistar rats fed for 60 days a glucose diet containing 17.5 mmol hexachlorobenzene/kg show a less pronounced increase in serum parameters and microsomal cytochrome P-450 concentration and a lower decrease in liver plasma membrane 5'-nucleotidase, K+, Na+- and Mg++-adenosine triphosphatase activities than the controls fed standard diet + hexachlorobenzene. Addition of 10% ethanol to the drinking water eliminates the "glucose effect". The glucose diet and ethanol exert contrasting effects on microsomal enzyme induction and liver plasma membrane damage in hexachlorobenzene intoxication.
ISSN:0340-5761
1432-0738
DOI:10.1007/BF00296961