A single dose study of the effects of fenoldopam and enalapril in mild hypertension

To clarify the contribution made by the renin-angiotensin system activation to the short lived hypotensive response to fenoldopam, the haemodynamic effects of a combination of fenoldopam (100 mg) and enalapril (5 mg) were compared with fenoldopam alone, enalapril alone and placebo in a balanced, ran...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1991-01, Vol.40 (3), p.231-236
Main Authors: MACDONALD, T. M, JEFFREY, R. F, FREESTONE, S, LEE, M. R
Format: Article
Language:English
Subjects:
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - analogs & derivatives
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - therapeutic use
Adult
Antihypertensive agents
Biological and medical sciences
Blood Pressure - drug effects
Cardiovascular system
Creatinine - metabolism
Dopamine Agents - therapeutic use
Double-Blind Method
Drug Synergism
Drug Therapy, Combination
Enalapril - therapeutic use
Fenoldopam
Humans
Hypertension - drug therapy
Medical sciences
Middle Aged
Natriuresis - drug effects
Pharmacology. Drug treatments
Posture - physiology
Pulse - drug effects
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Summary:To clarify the contribution made by the renin-angiotensin system activation to the short lived hypotensive response to fenoldopam, the haemodynamic effects of a combination of fenoldopam (100 mg) and enalapril (5 mg) were compared with fenoldopam alone, enalapril alone and placebo in a balanced, randomised, double blind, single dose study in eight hypertensive patients. Fenoldopam caused an acute fall in blood pressure which lasted approximately 3 h after dosing and was associated with a reflex tachycardia. Enalapril caused a more gradual fall in blood pressure (onset 2 h) without a reflex tachycardia. The combination of drugs produced greater reductions in blood pressure sustained for a longer period than fenoldopam alone and with a more rapid onset than enalapril alone. In combination the hypotensive effects of fenoldopam and enalapril were clearly additive and not synergistic. Activation of the renin-angiotensin system does not antagonise significantly the hypotensive effect of fenoldopam.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00315201