Cytogenetic investigations on children with acute non-lymphocytic leukemia

Cytogenetic data from 30 children with acute non-lymphocytic leukemia (ANLL) are evaluated in connection with patient's age, morphological type of leukemia and prognosis. In 20 out of 30 patients clonal chromosome aberrations were found. The frequency of chromosome aberrations and the prognosti...

Full description

Saved in:
Bibliographic Details
Published in:Blut 1988-06, Vol.56 (6), p.249-255
Main Authors: OLAH, E, BALOGH, E, SZOLLAR, J, SZAKMARY, E, KOVACS, I, SCHULER, D, KARMAZSIN, L
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Aging - genetics
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Child
Child, Preschool
Chromosome Aberrations
Chromosome Banding
Hematologic and hematopoietic diseases
Humans
Infant
Leukemia - drug therapy
Leukemia - genetics
Leukemia - mortality
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Prognosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cytogenetic data from 30 children with acute non-lymphocytic leukemia (ANLL) are evaluated in connection with patient's age, morphological type of leukemia and prognosis. In 20 out of 30 patients clonal chromosome aberrations were found. The frequency of chromosome aberrations and the prognostic parameters in the various morphological and age groups proved to be different and no direct relationship could be found in a given group between the frequency of aberrations and the prognosis. A more detailed analysis of data, however, provided some evidence that chromosome aberrations observed at diagnosis had a prognostic value independent of age and the morphological properties of blast cells: the normal karyotype and the pseudodiploidy proved to be of a favorable value but the hyperdiploidy and polyploidy an unfavorable prognostic parameter. Besides the known cytogenetic differences between childhood and adult ANLL, some similarities are also emphasized.
ISSN:0006-5242
1432-0584
DOI:10.1007/BF00320283