The contribution of leukocyte proteases to fibrinolysis

Polymorphonuclear leukocytes accumulate within blood clots and may contribute to fibrinolysis. The primary fibrinolytic enzymes of neutrophils are cathepsin G and elastase. Fibrin can be exposed to these granular enzymes as a result of cell lysis, phagocytosis of fibrin, or secretion of the enzymes...

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Bibliographic Details
Published in:Blut 1986-07, Vol.53 (1), p.1-9
Main Author: PLOW, E. F
Format: Article
Language:English
Subjects:
Animals
Applied sciences
Biological and medical sciences
Blood Coagulation
Blood coagulation. Blood cells
Exact sciences and technology
Fibrinogen - physiology
Fibrinolysis
Fundamental and applied biological sciences. Psychology
General aspects, investigation methods, hemostasis, fibrinolysis
Humans
Immune Sera - immunology
Leukocytes - enzymology
Molecular and cellular biology
Other techniques and industries
Pancreatic Elastase - immunology
Pancreatic Elastase - physiology
Peptide Hydrolases - physiology
Rabbits - immunology
Radioimmunoassay
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Summary:Polymorphonuclear leukocytes accumulate within blood clots and may contribute to fibrinolysis. The primary fibrinolytic enzymes of neutrophils are cathepsin G and elastase. Fibrin can be exposed to these granular enzymes as a result of cell lysis, phagocytosis of fibrin, or secretion of the enzymes from the cells. Neutrophil secretion occurs in association with blood coagulation and is dependent upon a plasma factor(s) and calcium. After secretion, the enzymes can degrade fibrin within a plasma environment. This is demonstrated by the inhibition of fibrinolysis by specific inhibitors of elastase and the augmentation of fibrinolysis by neutralization of the primary plasma inhibitor of elastase, alpha 1-proteinase inhibitor. A radioimmunoassay which discriminates elastase from plasmic degradation products of fibrinogen has been developed. In this assay, elastase elicited degradation products of fibrin(ogen) were detected in certain pathophysiologic plasma samples. Taken together, these findings indicate a role for leukocyte proteases in physiological fibrinolysis.
ISSN:0006-5242
1432-0584
DOI:10.1007/bf00320577