Lymphocytic plasmocytoid lymphoma with a three-banded gammopathy: reactivity of one of these paraproteins with cytomegalovirus

We report the case of a 70-year-old woman suffering from small lymphocytic, plasmocytoid lymphoma with abdominal lymphomas and infiltration of the lung and the bone marrow. A three-banded, IgG lambda, IgM lambda and IgA lambda-paraproteinemia was determined using immunofixation. Because of the patie...

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Bibliographic Details
Published in:Blut 1987, Vol.54 (1), p.25-32
Main Authors: KÖHLER, M, DAUS, H, KÖHLER, G, SCHLIMMER, P, WERNERT, N, SCHEURLEN, P. G
Format: Article
Language:English
Subjects:
Aged
Antibodies, Viral - immunology
Antigen-Antibody Reactions
Antigens, Viral - immunology
Biological and medical sciences
Blood Protein Electrophoresis
cytomegalovirus
Cytomegalovirus - immunology
Female
Hematologic and hematopoietic diseases
Humans
Immunoglobulin lambda-Chains - immunology
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Paraproteins - immunology
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Summary:We report the case of a 70-year-old woman suffering from small lymphocytic, plasmocytoid lymphoma with abdominal lymphomas and infiltration of the lung and the bone marrow. A three-banded, IgG lambda, IgM lambda and IgA lambda-paraproteinemia was determined using immunofixation. Because of the patient's high antibody titre against cytomegalovirus (CMV), the possible reactivity of these paraproteins with CMV was studied. The immunoglobulins were transferred to nitrocellulose sheets by a contact diffusion blotting system. CMV was applied to these sheets and the IgG lambda-paraprotein was shown to bind CMV. The reactivity of only one of the paraproteins with CMV suggests an oligoclonal origin of this gammopathy. In addition to the malignant disease an abnormal immune response to a CMV infection could be the cause of this three-banded gammopathy.
ISSN:0006-5242
1432-0584
DOI:10.1007/BF00326023