Dimethoate-induced toxic cardiac failure in the guinea pig

In anaesthetized guinea-pigs treated with lethal doses of dimethoate, cardiac failure and serious ECG disturbances developed in the early phase of intoxication. The toxic cardiac phenomena appeared to be unrelated to the degree of cholinesterase inhibition, but showed a close correlation with myocar...

Full description

Saved in:
Bibliographic Details
Published in:Archives of toxicology 1985-06, Vol.57 (2), p.142-143
Main Authors: MAROSI, G, IVAN, J, NAGYMAJTENYI, L, CSATLOS, I, TOSZEGI, A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cholinesterases - metabolism
Dimethoate - analogs & derivatives
Dimethoate - metabolism
Dimethoate - poisoning
Erythrocytes - enzymology
Guinea Pigs
Male
Medical sciences
Myocardium - metabolism
Pesticides, fertilizers and other agrochemicals toxicology
Shock, Cardiogenic - chemically induced
Shock, Cardiogenic - metabolism
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In anaesthetized guinea-pigs treated with lethal doses of dimethoate, cardiac failure and serious ECG disturbances developed in the early phase of intoxication. The toxic cardiac phenomena appeared to be unrelated to the degree of cholinesterase inhibition, but showed a close correlation with myocardial dimethoate concentration. Cardiac failure and mortality were first observed at a critical pesticide level of about 110 micrograms/g, while a level of 221 micrograms/g resulted in death in all cases. The present investigation refers to the direct effect of the pesticide on the myocardium, independent of its anticholinesterase action.
ISSN:0340-5761
1432-0738
DOI:10.1007/BF00343126