Retinoic acid in the anteroposterior patterning of the zebrafish trunk

Retinoic acid has been linked to pattern formation in the vertebrate anteroposterior axis. This report describes the spatial and temporal distributions of both endogenous retinoic acid and retinoic acid synthase activity along the anteroposterior axis of neurulating zebrafish embryos, as detected by...

Full description

Saved in:
Bibliographic Details
Published in:Roux's Archives of Developmental Biology 1995-11, Vol.205 (3-4), p.103-113
Main Authors: Marsh-Armstrong, Nicholas, McCaffery, Peter, Hyatt, George, Alonso, Laura, Dowling, John E, Gilbert, Walter, Dräger, Ursula C
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c351t-a715b459e4739cc582b66eb74623f75f227c813d2bcd85b076257a74e4231aeb3
cites cdi_FETCH-LOGICAL-c351t-a715b459e4739cc582b66eb74623f75f227c813d2bcd85b076257a74e4231aeb3
container_end_page 113
container_issue 3-4
container_start_page 103
container_title Roux's Archives of Developmental Biology
container_volume 205
creator Marsh-Armstrong, Nicholas
McCaffery, Peter
Hyatt, George
Alonso, Laura
Dowling, John E
Gilbert, Walter
Dräger, Ursula C
description Retinoic acid has been linked to pattern formation in the vertebrate anteroposterior axis. This report describes the spatial and temporal distributions of both endogenous retinoic acid and retinoic acid synthase activity along the anteroposterior axis of neurulating zebrafish embryos, as detected by a transient transgenic assay and by a zymography bioassay. Both retinoic acid levels and synthase activity were found to be highest in anterior regions of the trunk at all of the stages which were analysed. The drug disulfiram inhibited retinoic acid synthase activity in the zebrafish trunk both in vitro and in vivo, and reduced retinoic acid levels in vivo. Disulfiram treatment of neurulating embryos resulted in larvae with hypertrophic wavy notochords, shortened spinal cords and deformed pectoral fins. The results support the hypothesis that retinoic acid plays a role in the coordination of axial patterning at the developing node/zone of involution, as well as in the subsequent development of anterior trunk structures such as the fins.
doi_str_mv 10.1007/BF00357756
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_BF00357756</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1878824014</sourcerecordid><originalsourceid>FETCH-LOGICAL-c351t-a715b459e4739cc582b66eb74623f75f227c813d2bcd85b076257a74e4231aeb3</originalsourceid><addsrcrecordid>eNpFkE1LAzEARIMotq5e_AGSowir-dykRy1WhYIgCr0tSTZro22yJtmD_nq3tuppBuYxhwfAKUaXGCFxdTNDiHIheLUHxphRUiKGF_tgjCYUlcO0GIGjlN4QqpAg7BCMiKSbjsdg9mSz88EZqIxroPMwLy1UPtsYupCGcCHCTuWheedfYWh_iC-ro2pdWsIce_9-DA5atUr2ZJcFeJndPk_vy_nj3cP0el4aynEulcBcMz6xTNCJMVwSXVVWC1YR2greEiKMxLQh2jSSayQqwoUSzDJCsbKaFuB8-9vF8NHblOu1S8auVsrb0KcaSyElYWiwUICLLWpiSCnatu6iW6v4WWNUb7zV_94G-Gz32-u1bf7QX1H0G3gvZwU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1878824014</pqid></control><display><type>article</type><title>Retinoic acid in the anteroposterior patterning of the zebrafish trunk</title><source>Springer Online Journal Archives</source><creator>Marsh-Armstrong, Nicholas ; McCaffery, Peter ; Hyatt, George ; Alonso, Laura ; Dowling, John E ; Gilbert, Walter ; Dräger, Ursula C</creator><creatorcontrib>Marsh-Armstrong, Nicholas ; McCaffery, Peter ; Hyatt, George ; Alonso, Laura ; Dowling, John E ; Gilbert, Walter ; Dräger, Ursula C</creatorcontrib><description>Retinoic acid has been linked to pattern formation in the vertebrate anteroposterior axis. This report describes the spatial and temporal distributions of both endogenous retinoic acid and retinoic acid synthase activity along the anteroposterior axis of neurulating zebrafish embryos, as detected by a transient transgenic assay and by a zymography bioassay. Both retinoic acid levels and synthase activity were found to be highest in anterior regions of the trunk at all of the stages which were analysed. The drug disulfiram inhibited retinoic acid synthase activity in the zebrafish trunk both in vitro and in vivo, and reduced retinoic acid levels in vivo. Disulfiram treatment of neurulating embryos resulted in larvae with hypertrophic wavy notochords, shortened spinal cords and deformed pectoral fins. The results support the hypothesis that retinoic acid plays a role in the coordination of axial patterning at the developing node/zone of involution, as well as in the subsequent development of anterior trunk structures such as the fins.</description><identifier>ISSN: 0930-035X</identifier><identifier>EISSN: 1432-041X</identifier><identifier>DOI: 10.1007/BF00357756</identifier><identifier>PMID: 28306071</identifier><language>eng</language><publisher>Germany</publisher><ispartof>Roux's Archives of Developmental Biology, 1995-11, Vol.205 (3-4), p.103-113</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-a715b459e4739cc582b66eb74623f75f227c813d2bcd85b076257a74e4231aeb3</citedby><cites>FETCH-LOGICAL-c351t-a715b459e4739cc582b66eb74623f75f227c813d2bcd85b076257a74e4231aeb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28306071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marsh-Armstrong, Nicholas</creatorcontrib><creatorcontrib>McCaffery, Peter</creatorcontrib><creatorcontrib>Hyatt, George</creatorcontrib><creatorcontrib>Alonso, Laura</creatorcontrib><creatorcontrib>Dowling, John E</creatorcontrib><creatorcontrib>Gilbert, Walter</creatorcontrib><creatorcontrib>Dräger, Ursula C</creatorcontrib><title>Retinoic acid in the anteroposterior patterning of the zebrafish trunk</title><title>Roux's Archives of Developmental Biology</title><addtitle>Roux Arch Dev Biol</addtitle><description>Retinoic acid has been linked to pattern formation in the vertebrate anteroposterior axis. This report describes the spatial and temporal distributions of both endogenous retinoic acid and retinoic acid synthase activity along the anteroposterior axis of neurulating zebrafish embryos, as detected by a transient transgenic assay and by a zymography bioassay. Both retinoic acid levels and synthase activity were found to be highest in anterior regions of the trunk at all of the stages which were analysed. The drug disulfiram inhibited retinoic acid synthase activity in the zebrafish trunk both in vitro and in vivo, and reduced retinoic acid levels in vivo. Disulfiram treatment of neurulating embryos resulted in larvae with hypertrophic wavy notochords, shortened spinal cords and deformed pectoral fins. The results support the hypothesis that retinoic acid plays a role in the coordination of axial patterning at the developing node/zone of involution, as well as in the subsequent development of anterior trunk structures such as the fins.</description><issn>0930-035X</issn><issn>1432-041X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNpFkE1LAzEARIMotq5e_AGSowir-dykRy1WhYIgCr0tSTZro22yJtmD_nq3tuppBuYxhwfAKUaXGCFxdTNDiHIheLUHxphRUiKGF_tgjCYUlcO0GIGjlN4QqpAg7BCMiKSbjsdg9mSz88EZqIxroPMwLy1UPtsYupCGcCHCTuWheedfYWh_iC-ro2pdWsIce_9-DA5atUr2ZJcFeJndPk_vy_nj3cP0el4aynEulcBcMz6xTNCJMVwSXVVWC1YR2greEiKMxLQh2jSSayQqwoUSzDJCsbKaFuB8-9vF8NHblOu1S8auVsrb0KcaSyElYWiwUICLLWpiSCnatu6iW6v4WWNUb7zV_94G-Gz32-u1bf7QX1H0G3gvZwU</recordid><startdate>199511</startdate><enddate>199511</enddate><creator>Marsh-Armstrong, Nicholas</creator><creator>McCaffery, Peter</creator><creator>Hyatt, George</creator><creator>Alonso, Laura</creator><creator>Dowling, John E</creator><creator>Gilbert, Walter</creator><creator>Dräger, Ursula C</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199511</creationdate><title>Retinoic acid in the anteroposterior patterning of the zebrafish trunk</title><author>Marsh-Armstrong, Nicholas ; McCaffery, Peter ; Hyatt, George ; Alonso, Laura ; Dowling, John E ; Gilbert, Walter ; Dräger, Ursula C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-a715b459e4739cc582b66eb74623f75f227c813d2bcd85b076257a74e4231aeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marsh-Armstrong, Nicholas</creatorcontrib><creatorcontrib>McCaffery, Peter</creatorcontrib><creatorcontrib>Hyatt, George</creatorcontrib><creatorcontrib>Alonso, Laura</creatorcontrib><creatorcontrib>Dowling, John E</creatorcontrib><creatorcontrib>Gilbert, Walter</creatorcontrib><creatorcontrib>Dräger, Ursula C</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Roux's Archives of Developmental Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marsh-Armstrong, Nicholas</au><au>McCaffery, Peter</au><au>Hyatt, George</au><au>Alonso, Laura</au><au>Dowling, John E</au><au>Gilbert, Walter</au><au>Dräger, Ursula C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinoic acid in the anteroposterior patterning of the zebrafish trunk</atitle><jtitle>Roux's Archives of Developmental Biology</jtitle><addtitle>Roux Arch Dev Biol</addtitle><date>1995-11</date><risdate>1995</risdate><volume>205</volume><issue>3-4</issue><spage>103</spage><epage>113</epage><pages>103-113</pages><issn>0930-035X</issn><eissn>1432-041X</eissn><abstract>Retinoic acid has been linked to pattern formation in the vertebrate anteroposterior axis. This report describes the spatial and temporal distributions of both endogenous retinoic acid and retinoic acid synthase activity along the anteroposterior axis of neurulating zebrafish embryos, as detected by a transient transgenic assay and by a zymography bioassay. Both retinoic acid levels and synthase activity were found to be highest in anterior regions of the trunk at all of the stages which were analysed. The drug disulfiram inhibited retinoic acid synthase activity in the zebrafish trunk both in vitro and in vivo, and reduced retinoic acid levels in vivo. Disulfiram treatment of neurulating embryos resulted in larvae with hypertrophic wavy notochords, shortened spinal cords and deformed pectoral fins. The results support the hypothesis that retinoic acid plays a role in the coordination of axial patterning at the developing node/zone of involution, as well as in the subsequent development of anterior trunk structures such as the fins.</abstract><cop>Germany</cop><pmid>28306071</pmid><doi>10.1007/BF00357756</doi><tpages>11</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0930-035X
ispartof Roux's Archives of Developmental Biology, 1995-11, Vol.205 (3-4), p.103-113
issn 0930-035X
1432-041X
language eng
recordid cdi_crossref_primary_10_1007_BF00357756
source Springer Online Journal Archives
title Retinoic acid in the anteroposterior patterning of the zebrafish trunk
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T23%3A01%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Retinoic%20acid%20in%20the%20anteroposterior%20patterning%20of%20the%20zebrafish%20trunk&rft.jtitle=Roux's%20Archives%20of%20Developmental%20Biology&rft.au=Marsh-Armstrong,%20Nicholas&rft.date=1995-11&rft.volume=205&rft.issue=3-4&rft.spage=103&rft.epage=113&rft.pages=103-113&rft.issn=0930-035X&rft.eissn=1432-041X&rft_id=info:doi/10.1007/BF00357756&rft_dat=%3Cproquest_cross%3E1878824014%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c351t-a715b459e4739cc582b66eb74623f75f227c813d2bcd85b076257a74e4231aeb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1878824014&rft_id=info:pmid/28306071&rfr_iscdi=true