Delayed dermal hypersensitivity in rhesus monkeys (Macaca mulatta) immunized against Plasmodium knowlesi

Eighteen Rhesus monkeys were immunized with a fresh or lyophilized antigen preparation obtained from erythrocytes infected with Plasmodium knowlesi. Sixteen of these monkeys showed a positive delayed hypersensitivity response when subsequently skin tested with the immunizing antigen. Ten of the 16 p...

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Bibliographic Details
Published in:Zeitschrift f r Parasitenkunde 1976-01, Vol.50 (1), p.31-42
Main Authors: Cabrera, E J, Speer, C A, Schenkel, R H, Barr, M L, Silverman, P H
Format: Article
Language:English
Subjects:
Animals
Antigens - analysis
Blood Cell Count
Female
Haplorhini
Hematocrit
Hypersensitivity, Delayed
Immunization
Intradermal Tests
Macaca mulatta
Malaria - blood
Malaria - immunology
Male
Plasmodium - immunology
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Summary:Eighteen Rhesus monkeys were immunized with a fresh or lyophilized antigen preparation obtained from erythrocytes infected with Plasmodium knowlesi. Sixteen of these monkeys showed a positive delayed hypersensitivity response when subsequently skin tested with the immunizing antigen. Ten of the 16 positive reactors survived a P, knowlesi challenge, the remaining 6 showed several indications of protection. None of the 18 control monkeys gave a positive skin reaction or survived the challenging inoculum. Macro- and microscopical evidence suggests that the dermal reaction is of a delayed type. Preliminary biochemical analysis of the antigen used in this experiment is included and its significance is discussed. Hematological data is also presented.
ISSN:0044-3255
1432-1955
DOI:10.1007/BF00389929