Possible in vivo formation of a carcinogenic substance from diethyl pyrocarbonate and ammonia

Development of lung tumors can be observed in Kid: CFLP mice treated intragastrically with diethyl pyrocarbonate and ammonia. The lung tumors may result from a carcinogenic substance, supposedly urethane, formed in vivo from diethyl pyrocarbonate in the presence of ammonia.

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 1980-06, Vol.97 (2), p.205-207
Main Authors: Uzv lgyi, E., Boj n, F.
Format: Article
Language:English
Subjects:
Ammonia - adverse effects
Animals
Diethyl Pyrocarbonate - adverse effects
Female
Formates - adverse effects
Lung Neoplasms - chemically induced
Mice
Mice, Inbred Strains
Neoplasms, Experimental - chemically induced
Urethane - chemical synthesis
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Description
Summary:Development of lung tumors can be observed in Kid: CFLP mice treated intragastrically with diethyl pyrocarbonate and ammonia. The lung tumors may result from a carcinogenic substance, supposedly urethane, formed in vivo from diethyl pyrocarbonate in the presence of ammonia.
ISSN:0171-5216
1432-1335
DOI:10.1007/BF00409907