Implications of malnutrition in chemical carcinogenesis

Epidemiological data indicate that life style, including dietary "imbalances", play a major role in etiology of human cancers. Although two thirds of the world population suffer from varying grades of protein-caloric malnutrition (PCM) today, no consistent pattern is found to be associated...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 1981-01, Vol.99 (1-2), p.77-86
Main Author: Deo, M G
Format: Article
Language:English
Subjects:
Adult
Animals
Carcinogens - metabolism
Cell Cycle
DNA - biosynthesis
Female
Humans
Liver - metabolism
Male
Middle Aged
Neoplasms - chemically induced
Protein-Energy Malnutrition - complications
Protein-Energy Malnutrition - immunology
Protein-Energy Malnutrition - physiopathology
Rats
Spermatogenesis
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Summary:Epidemiological data indicate that life style, including dietary "imbalances", play a major role in etiology of human cancers. Although two thirds of the world population suffer from varying grades of protein-caloric malnutrition (PCM) today, no consistent pattern is found to be associated wih PCM both in man and laboratory animals. At the tissue level, depression of cellular proliferation by prolongation of DNA-synthetic phase is a characteristic lesion of PCM. Due to changes in liver mixed function oxidases, metabolism of drugs is affected. The cell-mediated immunity is depressed and there is a defective mobilisation of macrophages. These alterations would modulate carcinogenesis; some tend to enhance, while others inhibit tumorigenesis. The balance of evidence suggest that PCM is unlikely to have dominant modulating influence on carcinogenesis.
ISSN:0171-5216
1432-1335
DOI:10.1007/BF00412445