Anxiety and sedation during a stressful situation after single dose of diazepam versus N-desmethyldiazepam--a controlled trial

Twenty milligram diazepam (DZ) was compared with 20 mg of its main metabolite N-desmethyldiazepam (NDDZ) as single dose, oral premedication in a genuine stressful situation. Fifty patients participated in the randomized, double-blind controlled study. Anxiety and sedation were measured the day befor...

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Bibliographic Details
Published in:Psychopharmacology 1980-01, Vol.70 (3), p.303-305
Main Authors: Hendel, J, Elsass, P, Sørensen, K H, Møller, I W, Hvidberg, E F, Hansen, T
Format: Article
Language:English
Subjects:
Adult
Anxiety - drug therapy
Anxiety - etiology
Breast Neoplasms - complications
Diazepam - adverse effects
Diazepam - analogs & derivatives
Diazepam - therapeutic use
Double-Blind Method
Drug Evaluation
Emotions - drug effects
Female
Humans
Hypnotics and Sedatives
Middle Aged
Nordazepam - adverse effects
Nordazepam - therapeutic use
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Summary:Twenty milligram diazepam (DZ) was compared with 20 mg of its main metabolite N-desmethyldiazepam (NDDZ) as single dose, oral premedication in a genuine stressful situation. Fifty patients participated in the randomized, double-blind controlled study. Anxiety and sedation were measured the day before an operation and one hour after premedication, just before the operation. NDDZ was significantly less sedative while the degree of anxiety was rated equal in the two groups. The results may support the hypothesis that a competition between DZ and NDDZ can explain the shift in the effect profile of DZ during long term treatment.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00427891