Histochemical analysis of senile plaque amyloid and amyloid angiopathy

Histochemical methods were used to obtain information on the chemical constituents of brain amyloid in senile dementia of the Alzheimer type. The staining properties of brain amyloid (senile plaque and amyloid angiopathy) were compared with those of extraneural amyloidosis and endocrine amyloid. We...

Full description

Saved in:
Bibliographic Details
Published in:Virchows Archiv A Pathological Anatomy and Histology 1980-10, Vol.388 (3), p.327-334
Main Authors: Probst, A, Heitz, P U, Ulrich, J
Format: Article
Language:English
Subjects:
Adult
Aged
Alzheimer Disease - pathology
Amino Acids - analysis
Amyloid - analysis
Amyloidosis - pathology
APUD Cells - analysis
Dementia - pathology
Female
Humans
Male
Middle Aged
Serum Amyloid A Protein - analysis
Staining and Labeling
Vascular Diseases - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Histochemical methods were used to obtain information on the chemical constituents of brain amyloid in senile dementia of the Alzheimer type. The staining properties of brain amyloid (senile plaque and amyloid angiopathy) were compared with those of extraneural amyloidosis and endocrine amyloid. We found no histochemical differences between amyloid in senile plaques and in amyloid angiopathy. The content of aromatic amino acids was higher in amyloid of plaques and in amyloid angiopathy than in endocrine amyloid. Furthermore, we found persistent birefringence and affinity of brain amyloid for Congo red after exposure to potassium permanganate, suggesting that AA amyloid is not a major constituent of cerebral amyloid.
ISSN:0340-1227
1432-2307
DOI:10.1007/bf00430862