Choriocarcinomatous change with immunocytochemically HCG-positive cells in the gastric carcinoma of the males

Gastric choriocarcinoma is a rare tumor and attracts interest because of its controversial pathogenesis. The present study reports a choriocarcinomatous change with immunocytochemically hCG-positive cells in the gastric carcinoma. The patients were males, one was 41 years old and the other 42 years...

Full description

Saved in:
Bibliographic Details
Published in:Virchows Archiv A Pathological Anatomy and Histology 1982-01, Vol.396 (2), p.141-153
Main Authors: Mori, H, Soeda, O, Kamano, T, Tsunekawa, K, Ueda, N, Yoshida, A, Fukunishi, R
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adult
Aged
Choriocarcinoma - metabolism
Choriocarcinoma - pathology
Chorionic Gonadotropin - metabolism
Histocytochemistry
Hormones, Ectopic - metabolism
Humans
Immunologic Techniques
Male
Middle Aged
Neoplasms, Multiple Primary - metabolism
Placental Lactogen - metabolism
Pregnancy-Specific beta 1-Glycoproteins - metabolism
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gastric choriocarcinoma is a rare tumor and attracts interest because of its controversial pathogenesis. The present study reports a choriocarcinomatous change with immunocytochemically hCG-positive cells in the gastric carcinoma. The patients were males, one was 41 years old and the other 42 years old. The tumor of both cases consists of adenocarcinoma and choriocarcinoma. A sequential process of morphological transition of the adenocarcinoma to the choriocarcinoma can be traced. Indirect immunoperoxidase stain (PAP method) for human chorionic gonadotropin (hCG) demonstrates the localization of hCG in the syncytiotrophoblasts. Small number of cytotrophoblasts are weakly positive. None of the components of adenocarcinoma of both cases is positive for hCG. Human placental lactogen is not demonstrated in both cases. Stain for pregnancy specific beta-1 glycoprotein is weakly positive in the adenocarcinoma of one case but not in the choriocarcinoma. In one case, the concentration of hCG was 19.9 mIU/ml in the preoperative serum and decreased to 1.2 mIU/ml after gastrectomy. HCG production by gastric carcinoma was discussed with regard to possible pathogenesis of gastric choriocarcinoma.
ISSN:0340-1227
1432-2307
DOI:10.1007/bf00431237