Effect of muscimol, a central GABA receptor agonist, on the catalepsy, striatal homovanillic acid increase, and analgesia induced by pilocarpine in rats

Muscimol, a structural analog of GABA, significantly potentiated pilocarpine-induced analgesia in rats, but failed to alter pilocarpine-induced catalepsy. It also failed to affect pilocarpine-elicited increase in homovanillic acid levels in the striatum. These findings suggest that the potentiation...

Full description

Saved in:
Bibliographic Details
Published in:Psychopharmacology 1981-01, Vol.74 (4), p.393-394
Main Authors: Naik, S R, Kelkar, M R, Amladi, S R, Sheth, U K
Format: Article
Language:English
Subjects:
Analgesics
Animals
Catalepsy - chemically induced
Corpus Striatum - metabolism
Drug Interactions
Homovanillic Acid - metabolism
Humans
Male
Muscimol - pharmacology
Oxazoles - pharmacology
Phenylacetates - metabolism
Pilocarpine - pharmacology
Pilocarpine - toxicity
Rats
Rats, Inbred Strains
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Muscimol, a structural analog of GABA, significantly potentiated pilocarpine-induced analgesia in rats, but failed to alter pilocarpine-induced catalepsy. It also failed to affect pilocarpine-elicited increase in homovanillic acid levels in the striatum. These findings suggest that the potentiation of pilocarpine-induced analgesia by muscimol is unrelated to an interaction of the GABAergic system with the striatal cholinergic or dopaminergic systems.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00432756