Propofol-ketamine technique

Case reports are presented demonstrating a new, safe, and simple intravenous technique for outpatient anesthesia. Vinnik's technique requires hypnotic doses of diazepam (Valium) to prevent ketamine-induced hallucinations. The initial hypothesis tested in this clinical series was whether hypnoti...

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Bibliographic Details
Published in:Aesthetic plastic surgery 1993, Vol.17 (4), p.297-300
Main Author: FRIEDBERG, B. L
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Ambulatory Surgical Procedures
Anesthesia, Intravenous
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Dose-Response Relationship, Drug
Female
Hallucinations - chemically induced
Hallucinations - prevention & control
Humans
Ketamine - adverse effects
Male
Medical sciences
Midazolam
Middle Aged
Neurologic Examination - drug effects
Neuropharmacology
Pharmacology. Drug treatments
Preanesthetic Medication
Propofol
Surgery, Plastic
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Summary:Case reports are presented demonstrating a new, safe, and simple intravenous technique for outpatient anesthesia. Vinnik's technique requires hypnotic doses of diazepam (Valium) to prevent ketamine-induced hallucinations. The initial hypothesis tested in this clinical series was whether hypnotic doses of propofol would prevent hallucinations from ketamine as satisfactorily as diazepam. Once the initial hypothesis was confirmed, consideration was given to moderating the cost of propofol by determining the effect of two levels of midazolam premedication on propofol requirements. Hypnotic doses of propofol do prevent ketamine-induced hallucinations. It is possible to achieve significant propofol savings by premedication with midazolam without compromising patient readiness for discharge by the end of the first postoperative hour.
ISSN:0364-216X
1432-5241
DOI:10.1007/BF00437102