Superoxide dismutase and glutathione peroxidase in polymorphonuclear leucocytes

Superoxide dismutase (SOD) and glutathione peroxidase (GPX) protect aerobic organisms against the toxic superoxide anion and hydrogen peroxide, which are generated during phagocytosis by polymorphonuclear leucocytes (PMNs). PMNs of children with bacterial infections and with infectious hepatitis con...

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Bibliographic Details
Published in:European journal of pediatrics 1979-02, Vol.130 (2), p.127-136
Main Authors: Rister, M, Bauermeister, K, Gravert, U, Gladtke, E
Format: Article
Language:English
Subjects:
Age Factors
Arthritis, Juvenile - enzymology
Bacterial Infections - enzymology
Child
Female
Glutathione Peroxidase - blood
Hepatitis A - enzymology
Humans
Leukocytes - enzymology
Male
Peroxidases - blood
Phagocytosis
Sex Factors
Superoxide Dismutase - blood
Virus Diseases - enzymology
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Summary:Superoxide dismutase (SOD) and glutathione peroxidase (GPX) protect aerobic organisms against the toxic superoxide anion and hydrogen peroxide, which are generated during phagocytosis by polymorphonuclear leucocytes (PMNs). PMNs of children with bacterial infections and with infectious hepatitis contained significantly elevated SOD activity, whereas GPX activity remained in the normal range. In contrast, PMNs of children with viral infections and rheumatoid arthritis exhibited a decreased SOD activity, while GPX activity was again unchanged. The children's age, sex or treatment did not effect the enzyme activities in PMNs. Since SOD generates bactericidal hydrogen peroxide and regulates the release of the toxic superoxide radical into the surrounding tissues, this study may add new understanding to the pathophysiological aspects of acute and chronic inflammatory processes.
ISSN:0340-6199
1432-1076
DOI:10.1007/BF00442349