Intracranial bleeding during therapy with L-asparaginase in childhood acute lymphocytic leukemia

Two patients developed clinical features of intracranial bleeding--which were confirmed by computerized axial tomograms--during their induction therapy for acute lymphocytic leukemia. Coagulation studies showed clotting abnormalities including severe hypofibrinogenemia. These findings most probably...

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Bibliographic Details
Published in:European journal of pediatrics 1981-11, Vol.137 (3), p.323-327
Main Authors: Urban, C, Sager, W D
Format: Article
Language:English
Subjects:
Asparaginase - adverse effects
Cerebral Hemorrhage - chemically induced
Cerebral Hemorrhage - diagnosis
Child
Child, Preschool
Fibrinogen - analysis
Humans
Leukemia, Lymphoid - drug therapy
Male
Tomography, X-Ray Computed
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Summary:Two patients developed clinical features of intracranial bleeding--which were confirmed by computerized axial tomograms--during their induction therapy for acute lymphocytic leukemia. Coagulation studies showed clotting abnormalities including severe hypofibrinogenemia. These findings most probably were related to the effect of L-asparaginase which was part of the treatment protocol. Central nervous system leukemia, intrathecal chemotherapy, cranial irradiation, extreme leukocytosis, or thrombopenia at the time of diagnosis or day of stroke did not appear to be predisposing factors in these cases.
ISSN:0340-6199
1432-1076
DOI:10.1007/BF00443266