Increased bone radiotracer uptake in renal osteodystrophy. Clinical evidence of hyperparathyroidism as the major cause

Bone radiotracer uptake in renal osteodystrophy was investigated in 35 dialysis patients by correlating the results of quantitative bone scintigraphy with those of biochemical and bone morphometric studies. There were highly significant correlations (P less than 0.001) between the total skeletal act...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1982-01, Vol.7 (4), p.152-154
Main Authors: de Graaf, P, te Velde, J, Pauwels, E K, Schicht, I M, Kleiverda, K, de Graeff, J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bone and Bones - diagnostic imaging
Bone and Bones - pathology
Chronic Kidney Disease-Mineral and Bone Disorder - diagnostic imaging
Chronic Kidney Disease-Mineral and Bone Disorder - etiology
Chronic Kidney Disease-Mineral and Bone Disorder - metabolism
Female
Humans
Hyperparathyroidism - complications
Hyperparathyroidism - metabolism
Kidney Failure, Chronic - therapy
Male
Middle Aged
Radionuclide Imaging
Renal Dialysis
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Summary:Bone radiotracer uptake in renal osteodystrophy was investigated in 35 dialysis patients by correlating the results of quantitative bone scintigraphy with those of biochemical and bone morphometric studies. There were highly significant correlations (P less than 0.001) between the total skeletal activity and the biochemical (iPTH and alkaline phosphatase), and histologic parameters of hyperparathyroidism. These clinical results strongly suggest that increased bone turnover i.e. hyperparathyroidism, rather than osteomalacia is the major cause of increased skeletal uptake in renal osteodystrophy.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00443921