Effects of iron and desferrioxamine on Rhizopus infection

To investigate the association among iron, desferrioxamine, and a Rhizopus infection, the influence of iron and/or desferrioxamine on experimental mucormycosis in mice was examined. All mice pretreated with iron, desferrioxamine, or a combination of iron and desferrioxamine died within 5 days after...

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Bibliographic Details
Published in:Mycopathologia (1975) 1990-05, Vol.110 (2), p.87-91
Main Authors: ABE, F, INABA, H, KATOH, T, HOTCHI, M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - pathology
Deferoxamine - adverse effects
Drug Interactions
Fundamental and applied biological sciences. Psychology
Growth, nutrition, metabolism, transports, enzymes. Molecular biology
Iron - adverse effects
Iron - blood
Kidney - pathology
Male
Mice
Mice, Inbred ICR
Microbiology
Mucormycosis - blood
Mucormycosis - microbiology
Mucormycosis - pathology
Mycology
Rhizopus - pathogenicity
Specific Pathogen-Free Organisms
Virulence
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Summary:To investigate the association among iron, desferrioxamine, and a Rhizopus infection, the influence of iron and/or desferrioxamine on experimental mucormycosis in mice was examined. All mice pretreated with iron, desferrioxamine, or a combination of iron and desferrioxamine died within 5 days after the inoculation of R. oryzae. In the mice fungal lesions were observed in the brain which resembled human cerebral mucormycosis. By contrast, the mortality in the control mice with R. oryzae was 20% through the 3-week experimental period. Therefore, it was demonstrated that iron as well as desferrioxamine administration markedly promotes the growth of R. oryzae. The increased susceptibility to R. oryzae was considered to be due to increased serum iron in the animals pretreated with iron only; however, pretreatment with desferrioxamine did not affect the amount of serum ion. Thus, the data suggest that desferrioxamine acts as a siderophore to R. oryzae and exerts an adverse effect on mucormycosis. This study has shown that the presence of iron and desferrioxamine enhances the virulence and pathogenicity of R. oryzae by serving as a growth factor.
ISSN:0301-486X
1573-0832
DOI:10.1007/BF00446996