Photoallergic dermatitis from 8-methoxypsoralen

A 36 year old woman with psoriasis vulgaris developed generalized photoallergic dermatitis to 8-methoxypsoralen after 16 uneventful treatments with 8-methoxypsoralen und UVA (PUVA). The diagnosis of photoallergy was confirmed by re-exposure to oral 8-methoxypsoralen and total body UVA irradiation; p...

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Bibliographic Details
Published in:Archives of Dermatological Research 1978-01, Vol.261 (2), p.201-211
Main Authors: Plewig, G, Hofmann, C, Braun-Falco, O
Format: Article
Language:English
Subjects:
Adult
Drug Eruptions - etiology
Drug Eruptions - pathology
Female
Humans
Methoxsalen - adverse effects
Photochemotherapy - adverse effects
Photosensitivity Disorders - chemically induced
Photosensitivity Disorders - pathology
Psoriasis - drug therapy
Ultraviolet Rays
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Summary:A 36 year old woman with psoriasis vulgaris developed generalized photoallergic dermatitis to 8-methoxypsoralen after 16 uneventful treatments with 8-methoxypsoralen und UVA (PUVA). The diagnosis of photoallergy was confirmed by re-exposure to oral 8-methoxypsoralen and total body UVA irradiation; phototests using topical and oral 8-methoxypsoralen with a high intensity monochromator or with a new high intensity light apparatus for the delivery of UVA; and histological studies. Photoallergy occurred only with UVA, but not with UVB or UVC. There was no photoallergy following trimethylpsoralen.
ISSN:0340-3696
1432-069X
DOI:10.1007/BF00447165