Albumin-directed antibodies in diabetes: demonstration of human serum albumin-directed IgM autoantibodies

Sera of 406 individuals, 174 Type 1 (insulin-dependent) diabetic patients, 125 non-diabetic family members and 107 unrelated control subjects, were screened for the presence of antibodies against glycated albumin. In none of these sera could such antibodies be detected. However, antibodies directed...

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Bibliographic Details
Published in:Diabetologia 1986-08, Vol.29 (8), p.481-484
Main Authors: GREGOR, I, IBERG, N, BERGER, W, FLUCKIGER, R
Format: Article
Language:English
Subjects:
Autoantibodies - isolation & purification
Biological and medical sciences
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - immunology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Glycosylation
Humans
Immunoglobulin M - isolation & purification
Male
Medical sciences
Serum Albumin - immunology
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Summary:Sera of 406 individuals, 174 Type 1 (insulin-dependent) diabetic patients, 125 non-diabetic family members and 107 unrelated control subjects, were screened for the presence of antibodies against glycated albumin. In none of these sera could such antibodies be detected. However, antibodies directed towards monomeric, unmodified human serum albumin were detected in 13 sera. These albumin autoantibodies were of the IgM class, and occurred in sera from nondiabetic persons (0.9-1.6%) and with a five-fold higher frequency in sera from diabetic patients (5.2%). The presence of albumin antibodies was neither related to the presence of diabetic late complications, islet cell antibodies, HLA-status nor duration of diabetes. The albumin antibodies were also found in sera from persons carrying antibodies against mumps (17%) or Epstein-Barr virus.
ISSN:0012-186X
1432-0428
DOI:10.1007/BF00453497