The fine structure of HNK-1 (Leu7) positive cells. A study using an immunoperoxidase technique

The ultrastructural characteristics of HNK-1 (Leu7) positive cells, visualized with a peroxidase labelled anti-mouse IgM serum, were analysed. Our investigation demonstrates: 1) the majority of Leu7 positive cells has a low nuclear/cytoplasmic ratio (N/C), an irregular outline, a well developed smoo...

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Bibliographic Details
Published in:Histochemistry 1984-01, Vol.81 (2), p.153-155
Main Authors: Manara, G C, de Panfilis, G, Ferrari, C, Bonati, A, Scandroglio, R
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal
Cytoplasmic Granules - ultrastructure
Humans
Immunoenzyme Techniques
Killer Cells, Natural - immunology
Killer Cells, Natural - ultrastructure
Middle Aged
Phenotype
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Summary:The ultrastructural characteristics of HNK-1 (Leu7) positive cells, visualized with a peroxidase labelled anti-mouse IgM serum, were analysed. Our investigation demonstrates: 1) the majority of Leu7 positive cells has a low nuclear/cytoplasmic ratio (N/C), an irregular outline, a well developed smooth endoplasmic reticulum, parallel tubular arrays (PTA) and electron dense granules; 2) the minority of Leu7 positive cells has a high N/C, regular profiles and lacks electron dense granules. The presence of two distinct ultrastructural patterns within Leu7 positive cells may represent: 1) the expression of subsequent stages of cell differentiation; 2) two distinct Leu7 positive cell subpopulations.
ISSN:0301-5564
1432-119X
DOI:10.1007/BF00490109