Cross-reaction of a monoclonal anti-filaggrin antibody with glycogen

A mouse monoclonal anti human filaggrin antibody was found to bind keratohyaline granules of normal epidermis as well as of premalignant and malignant lesions in formalin-fixed tissue sections. In addition, an unexpected binding of this antibody with cells containing glycogen and other PAS positive...

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Bibliographic Details
Published in:Histochemistry 1987-01, Vol.87 (6), p.597-600
Main Authors: VIGNESWARAN, N, HANEKE, E, PETERS, K.-P
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal
Biological and medical sciences
Cross Reactions
Dermatology
Glycogen - immunology
Humans
Intermediate Filament Proteins - immunology
Medical sciences
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:A mouse monoclonal anti human filaggrin antibody was found to bind keratohyaline granules of normal epidermis as well as of premalignant and malignant lesions in formalin-fixed tissue sections. In addition, an unexpected binding of this antibody with cells containing glycogen and other PAS positive substances was found, which could be abolished by adsorption of the anti-filaggrin antibody with glycogen or pretreatment of the sections with diastase.
ISSN:0301-5564
1432-119X
DOI:10.1007/bf00492476