Corneal lesions induced by the systemic administration of capsaicin in neonatal mice and rats

Following a single subcutaneous injection of capsaicin to neonatal mice, a high incidence of corneal lesions with opacity developed after a long latency. The intensity of the lesions progressed for about 1 month in animals which had received a high dose (50 or 100 mg/kg) of capsaicin. Although the i...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 1984-01, Vol.326 (4), p.347-351
Main Authors: SHIMIZU, T, FUJITA, S, IZUMI, K, KOJA, T, OHBA, N, FUKUDA, T
Format: Article
Language:English
Subjects:
Aging
Animals
Animals, Newborn
Biological and medical sciences
Capsaicin - toxicity
Corneal Opacity - chemically induced
Corneal Opacity - pathology
Drug toxicity and drugs side effects treatment
Female
Male
Medical sciences
Mice
Mice, Inbred BALB C
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
Sex Factors
Species Specificity
Time Factors
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Summary:Following a single subcutaneous injection of capsaicin to neonatal mice, a high incidence of corneal lesions with opacity developed after a long latency. The intensity of the lesions progressed for about 1 month in animals which had received a high dose (50 or 100 mg/kg) of capsaicin. Although the intensity gradually decreased thereafter, 50% of animals still exhibited a visible opacity 6 months after treatment. Similar corneal lesions were also produced in neonatal rats which had been injected with capsaicin. It is suggested that the corneal lesions induced by capsaicin may be due to destruction of the trigeminal nerve.
ISSN:0028-1298
1432-1912
DOI:10.1007/bf00501441