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Corneal lesions induced by the systemic administration of capsaicin in neonatal mice and rats

Following a single subcutaneous injection of capsaicin to neonatal mice, a high incidence of corneal lesions with opacity developed after a long latency. The intensity of the lesions progressed for about 1 month in animals which had received a high dose (50 or 100 mg/kg) of capsaicin. Although the i...

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Published in:	Naunyn-Schmiedeberg's archives of pharmacology 1984-01, Vol.326 (4), p.347-351
Main Authors:	SHIMIZU, T, FUJITA, S, IZUMI, K, KOJA, T, OHBA, N, FUKUDA, T
Format:	Article
Language:	English
Subjects:	Aging Animals Animals, Newborn Biological and medical sciences Capsaicin - toxicity Corneal Opacity - chemically induced Corneal Opacity - pathology Drug toxicity and drugs side effects treatment Female Male Medical sciences Mice Mice, Inbred BALB C Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Rats Rats, Inbred Strains Sex Factors Species Specificity Time Factors
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description	Following a single subcutaneous injection of capsaicin to neonatal mice, a high incidence of corneal lesions with opacity developed after a long latency. The intensity of the lesions progressed for about 1 month in animals which had received a high dose (50 or 100 mg/kg) of capsaicin. Although the intensity gradually decreased thereafter, 50% of animals still exhibited a visible opacity 6 months after treatment. Similar corneal lesions were also produced in neonatal rats which had been injected with capsaicin. It is suggested that the corneal lesions induced by capsaicin may be due to destruction of the trigeminal nerve.
doi_str_mv	10.1007/bf00501441
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It is suggested that the corneal lesions induced by capsaicin may be due to destruction of the trigeminal nerve.</description><subject>Aging</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Capsaicin - toxicity</subject><subject>Corneal Opacity - chemically induced</subject><subject>Corneal Opacity - pathology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pharmacology. 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identifier	ISSN: 0028-1298
ispartof	Naunyn-Schmiedeberg's archives of pharmacology, 1984-01, Vol.326 (4), p.347-351
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source	Springer Online Journal Archives (Through 1996)
subjects	Aging Animals Animals, Newborn Biological and medical sciences Capsaicin - toxicity Corneal Opacity - chemically induced Corneal Opacity - pathology Drug toxicity and drugs side effects treatment Female Male Medical sciences Mice Mice, Inbred BALB C Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Rats Rats, Inbred Strains Sex Factors Species Specificity Time Factors
title	Corneal lesions induced by the systemic administration of capsaicin in neonatal mice and rats
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