Ultrastructural localization of motilin in endocrine cells of human and dog intestine by the immunogold technique

Motilin-immunoreactivity has been localized by two electron immunocytochemical techniques, using gold-labelled protein A or IgG as second layer, in a specific type of endocrine cell scattered in the epithelium of human and canine upper small intestine. The motilin (M) cell is characterized by relati...

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Bibliographic Details
Published in:Histochemistry 1984-01, Vol.81 (4), p.363-368
Main Authors: USELLINI, L, BUCHAN, A. M. J, POLAK, J. M, CAPELLA, C, CORNAGGIA, M, SOLCIA, E
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dogs
Fundamental and applied biological sciences. Psychology
Gastrointestinal hormones
Gastrointestinal Hormones - metabolism
Gold
Histocytochemistry - methods
Humans
Immunochemistry
Immunoglobulin G
Intestine, Small - analysis
Intestine, Small - ultrastructure
Microscopy, Electron
Motilin - immunology
Motilin - metabolism
Staphylococcal Protein A
Vertebrates: digestive system
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Summary:Motilin-immunoreactivity has been localized by two electron immunocytochemical techniques, using gold-labelled protein A or IgG as second layer, in a specific type of endocrine cell scattered in the epithelium of human and canine upper small intestine. The motilin (M) cell is characterized by relatively small (180 nm in man; 200 nm in the dog), solid granules with homogeneous core and closely applied membrane, round in man, round to irregularly-shaped in the dog. Perinuclear microfilaments are prominent in human motilin cells.
ISSN:0301-5564
1432-119X
DOI:10.1007/bf00514330