Amiodarone and pulmonary fibrosis

Of 25 cases of idiopathic pulmonary fibrosis, confirmed by open chest lung biopsy between January 1979 and July 1981, 5 patients had been taking amiodarone in doses less than 600 mg daily for 1 to 6 years. No lung disease had been observed in any patient before the administration of amiodarone, and...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical pharmacology 1983-01, Vol.24 (5), p.591-593
Main Authors: Morera, J, Vidal, R, Morell, F, Ruiz, J, Bernadó, L, Laporte, J R
Format: Article
Language:English
Subjects:
Aged
Amiodarone - adverse effects
Benzofurans - adverse effects
Female
Humans
Male
Middle Aged
Pulmonary Fibrosis - chemically induced
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Of 25 cases of idiopathic pulmonary fibrosis, confirmed by open chest lung biopsy between January 1979 and July 1981, 5 patients had been taking amiodarone in doses less than 600 mg daily for 1 to 6 years. No lung disease had been observed in any patient before the administration of amiodarone, and other drugs, factors and diseases thought to play a role in the causation of pulmonary fibrosis were ruled out. Two patients died of respiratory insufficiency, and only 1 does not now suffer from serious sequelae. Review of a further 5 cases reported in the literature and the present data suggest a causal link between administration of amiodarone and pulmonary fibrosis, and tend to indicate a hypersensitivity mechanism.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00542206