Single and divided daily dose piretanide in the treatment of uncomplicated essential hypertension: a double-blind comparison with a combination of hydrochlorothiazide and amiloride

In a randomised double blind study in patients with mild to moderate hypertension, piretanide 6 mg once and twice daily significantly reduced both supine and erect blood pressure. This was seen after only 2 weeks and a further progressive reduction was evident over the ensuing 12-week trial period....

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Bibliographic Details
Published in:European journal of clinical pharmacology 1985-01, Vol.29 (3), p.269-273
Main Authors: VERHO, M, RANGOONWALA, B, DOLS, W
Format: Article
Language:English
Subjects:
Adult
Aged
Amiloride - administration & dosage
Amiloride - therapeutic use
Antihypertensive agents
Biological and medical sciences
Cardiovascular system
Clinical Trials as Topic
Double-Blind Method
Drug Therapy, Combination
Female
Humans
Hydrochlorothiazide - administration & dosage
Hydrochlorothiazide - adverse effects
Hydrochlorothiazide - therapeutic use
Hypertension - drug therapy
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Posture
Potassium - blood
Random Allocation
Sodium - blood
Sulfonamides - administration & dosage
Sulfonamides - adverse effects
Sulfonamides - therapeutic use
Time Factors
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Summary:In a randomised double blind study in patients with mild to moderate hypertension, piretanide 6 mg once and twice daily significantly reduced both supine and erect blood pressure. This was seen after only 2 weeks and a further progressive reduction was evident over the ensuing 12-week trial period. The higher dose produced a mean maximal fall of 29% in supine diastolic pressure, compared with 23% after the lower dose; the difference is not significant. Hydrochlorothiazide 50 mg/amiloride 5 mg twice daily (HCT/A) also reduced supine blood pressure significantly after 2 weeks, but the reduction in erect diastolic blood pressure did not achieve statistical significance until 8 weeks. The maximal effect (a 13% fall in supine diastolic blood pressure) was significantly less than that of either piretanide regimen. Blood pressures in this group also returned more rapidly to pretreatment levels during the placebo washout phase at the end of the study. HCT/A produced a significant sustained rise in serum potassium and a reduction in serum sodium and chloride. Piretanide had minimal effects on serum electrolytes.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00544079