Plasma propranolol steady state concentrations in thyroid disorders

Plasma propranolol steady-state concentrations (Css) were measured in 24 hyperthyroid and 6 hypothyroid patients before and after correction of the thyroid disorder. Following treatment of hyperthyroidism by surgery, antithyroid drugs or radioiodine, there was a significant rise in the plasma propra...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1981-01, Vol.19 (5), p.329-333
Main Authors: Feely, J, Crooks, J, Stevenson, I H
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Blood Proteins - metabolism
Humans
Hyperthyroidism - blood
Hyperthyroidism - therapy
Hypothyroidism - blood
Hypothyroidism - drug therapy
Middle Aged
Propranolol - blood
Protein Binding
Thyroxine - therapeutic use
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Summary:Plasma propranolol steady-state concentrations (Css) were measured in 24 hyperthyroid and 6 hypothyroid patients before and after correction of the thyroid disorder. Following treatment of hyperthyroidism by surgery, antithyroid drugs or radioiodine, there was a significant rise in the plasma propranolol Css in patients receiving propranolol either 160 mg/day, 240 mg/day, or 480 mg/day. In addition, in five patients the area under the plasma propranolol concentration versus time curve during a dosing interval increased significantly from 405 ng/ml/h when hyperthyroid to 778 ng/ml/h when euthyroid. In the hypothyroid patients given propranolol 160 mg/day concomitantly with 1-thyroxine therapy the plasma propranolol Css fell significantly when euthyroid. There was a small but significant increase in the degree of plasma protein binding of propranolol, following treatment of hyperthyroidism and a significant decrease following correction of hypothyroidism. It is concluded that thyroid disorders markedly influence propranolol handling.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00544582