The effect of buffered aspirin on plasma indomethacin

Plasma indomethacin levels have been compared in 10 subjects following 100 mg of indomethacin from two different formulations, with similar disintegration and dissolution profiles. In four of these ten subjects plasma indomethacin levels were estimated after pretreatment with, and concurrent adminis...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1975-02, Vol.8 (2), p.107-113
Main Authors: Garnham, J C, Raymond, K, Shotton, E, Turner, P
Format: Article
Language:English
Subjects:
Adult
Aspirin - administration & dosage
Aspirin - pharmacology
Biological Availability
Blood Proteins - metabolism
Buffers
Capsules
Drug Interactions
Female
Humans
In Vitro Techniques
Indomethacin - administration & dosage
Indomethacin - adverse effects
Indomethacin - blood
Male
Protein Binding
Solubility
Tablets
Time Factors
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Summary:Plasma indomethacin levels have been compared in 10 subjects following 100 mg of indomethacin from two different formulations, with similar disintegration and dissolution profiles. In four of these ten subjects plasma indomethacin levels were estimated after pretreatment with, and concurrent administration of, a buffered aspirin. The percentage of protein binding of indomethacin in the presence of salicylate was also estimated. No significant differences between peak plasma indomethacin levels with or without buffered aspirin were detected, but the rate of indomethacin absorption as shown by plasma levels, was significantly increased by pretreatment with and concurrent administration of, buffered aspirin. This was associated with a marked increase in side effects.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00561558