Intravenous administration of enprofylline to asthmatic patients

In 6 asthmatic patients, the possibility of obtaining a steady state plasma level of 5 mg/l of enprofylline by administration of two constant rate infusions was examined. The simulated plasma concentration curves, based on information from preassessment of individual pharmacokinetic parameters, were...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1983-01, Vol.24 (3), p.323-327
Main Authors: Laursen, L C, Johannesson, N, Fagerström, P O, Weeke, B
Format: Article
Language:English
Subjects:
Adult
Asthma - drug therapy
Clinical Trials as Topic
Double-Blind Method
Female
Humans
Infusions, Parenteral
Kinetics
Male
Middle Aged
Spirometry
Theophylline - therapeutic use
Xanthines - administration & dosage
Xanthines - adverse effects
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Summary:In 6 asthmatic patients, the possibility of obtaining a steady state plasma level of 5 mg/l of enprofylline by administration of two constant rate infusions was examined. The simulated plasma concentration curves, based on information from preassessment of individual pharmacokinetic parameters, were in good agreement with the plasma levels obtained. The side-effects and bronchodilatation produced by enprofylline were compared to those obtained with theophylline at a steady state level of 15 mg/l. Enprofylline and theophylline caused a mean maximal increase in FEV1.0 of 14% and 2.6% per mg/l in plasma, respectively. Side-effects, headache, nausea and vomiting, became pronounced in 2 patients in whom the plasma enprofylline level was about 6 mg/l. No other serious adverse reaction was seen. It is suggested that enprofylline should be further evaluated as a possible anti-asthmatic drug.
ISSN:0031-6970
1432-1041
DOI:10.1007/bf00610048