Alcohol-induced injury of mitochondria in hepatocytes of mini-pig fetuses

The present study describes the occurrence of abnormal mitochondria in the cytoplasm of hepatocytes from half-term mini-pig fetuses, whose mothers in addition to their ordinary fodder have received alcohol (ethanol) in daily amounts comparable to those consumed by human alcoholics. The abnormal mito...

Full description

Saved in:
Bibliographic Details
Published in:Virchows Archiv A Pathological Anatomy and Histopathology 1983, Vol.399 (3), p.299-305
Main Authors: Rømert, P, Matthiessen, M E
Format: Article
Language:English
Subjects:
Alcoholism - pathology
Animals
Female
Fetus
Humans
Maternal-Fetal Exchange
Microscopy, Electron
Mitochondria, Liver - ultrastructure
Pregnancy
Swine
Swine, Miniature
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The present study describes the occurrence of abnormal mitochondria in the cytoplasm of hepatocytes from half-term mini-pig fetuses, whose mothers in addition to their ordinary fodder have received alcohol (ethanol) in daily amounts comparable to those consumed by human alcoholics. The abnormal mitochondria exhibit elongation and distortion, disorientation of cristae and the appearance of paracrystalline and electron-dense material in the matrix. These ultrastructural changes show striking similarities to the mitochondrial injuries seen initially in the hepatocytes of human alcoholics and probably reflect damage to the mitochondria caused by alcohol itself.
ISSN:0174-7398
0340-1227
1432-2307
DOI:10.1007/BF00612947