99mTc-MAG3, a new renal imaging agent: preliminary results in patients

99mTc-mercaptoacetyltriglycine (MAG3) is a new renal radiopharmaceutical which has been shown to have biological properties similar to 131I-hippurate (OIH) in animals and volunteers. 99mTc-MAG3 has now been compared with 131I-orthoiodohippurate (OIH) in a group of patients with varying degrees of re...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1987, Vol.12 (10), p.510-514
Main Authors: Taylor, Jr, A, Eshima, D, Alazraki, N
Format: Article
Language:English
Subjects:
Adult
Female
Humans
Iodine Radioisotopes
Iodohippuric Acid
Kidney - diagnostic imaging
Kidney - physiopathology
Kidney Transplantation
Oligopeptides
Organometallic Compounds
Radionuclide Imaging
Technetium Tc 99m Mertiatide
Ureteral Obstruction - diagnostic imaging
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Summary:99mTc-mercaptoacetyltriglycine (MAG3) is a new renal radiopharmaceutical which has been shown to have biological properties similar to 131I-hippurate (OIH) in animals and volunteers. 99mTc-MAG3 has now been compared with 131I-orthoiodohippurate (OIH) in a group of patients with varying degrees of renal impairment. In all cases, the 99mTc-MAG3 images were superior regardless of serum creatinine. Selected examples are illustrated including scans and renogram curves in a normal volunteer, transplant patients with creatinines of 9.8 mg/dl and 2.6 mg/dl respectively, and a furosemide study in a patient with questionable obstruction. Our preliminary results suggest that 99mTc-MAG3 performs well in patients with impaired renal function and may well provide an acceptable replacement for OIH. A kit formulation has been developed and will soon be undergoing clinical evaluation.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00620476