Single dose prophylaxis with metronidazole in infants during abdominal surgery: a pharmacokinetic study

Plasma metronidazole was measured following a single intravenous dose of 20 mg/kg (Flagyl 5 mg/ml) in 12 infants less than 1 year of age undergoing abdominal surgery. In all patients sufficient plasma concentrations, well above the MIC values for anaerobic bacteria, were found for at least 16 h. A p...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1986-01, Vol.29 (5), p.625-628
Main Authors: RUBENSON, A, ROSETZSKY, A
Format: Article
Language:English
Subjects:
Abdomen - surgery
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Biological and medical sciences
Half-Life
Humans
Infant
Infant, Newborn
Kinetics
Medical sciences
Metronidazole - adverse effects
Metronidazole - therapeutic use
Pharmacology. Drug treatments
Premedication
Surgical Wound Infection - prevention & control
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Summary:Plasma metronidazole was measured following a single intravenous dose of 20 mg/kg (Flagyl 5 mg/ml) in 12 infants less than 1 year of age undergoing abdominal surgery. In all patients sufficient plasma concentrations, well above the MIC values for anaerobic bacteria, were found for at least 16 h. A prolonged half-life was demonstrated in the group less than 8 weeks of age (t1/2/18.4 h). The group over 8 weeks of age demonstrated a t1/2 comparable to that seen in adults (t1/2 7 h).
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00635904