The disposition and metabolism of (+)-cyanidanol-3 in patients with alcoholic cirrhosis

The effect of alcoholic cirrhosis of the liver on the disposition and metabolism of (+)-cyanidanol-3 has been studied in three patients. Following oral intake of U-14C-(+)-cyanidanol-3 2 g, the unchanged drug was detected in plasma between 0.5 and 24 h after dosing and the metabolites, measured only...

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Published in:European journal of clinical pharmacology 1987-01, Vol.33 (3), p.255-259
Main Authors: SMILLIE, M. V, GRIFFITHS, L. A, MALE, P. J, VERMEILLE, M. M
Format: Article
Language:English
Subjects:
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Catechin - blood
Catechin - pharmacokinetics
Catechin - urine
Erythrocytes - metabolism
Humans
Liver Cirrhosis, Alcoholic - metabolism
Liver Function Tests
Male
Medical sciences
Middle Aged
Toxicology
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Summary:The effect of alcoholic cirrhosis of the liver on the disposition and metabolism of (+)-cyanidanol-3 has been studied in three patients. Following oral intake of U-14C-(+)-cyanidanol-3 2 g, the unchanged drug was detected in plasma between 0.5 and 24 h after dosing and the metabolites, measured only as 14C-levels, were still detectable at 120 h. A mean of 55% of the dose was excreted in the urine, in which the major metabolites were the glucuronic and sulphuric acid conjugates of (+)-cyanidanol-3 and 3'-O-methyl-(+)-cyanidanol-3, although one patient excreted a larger proportion as non-conjugated metabolites. The pattern of metabolism in the patients did not differ significantly from that in control subjects, suggesting that the drug is handled by the cirrhotic liver in a similar manner to the normal liver.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00637558