Intractable diarrhoea associated with continuation of cytotoxic chemotherapy during acute infective enteritis

Severe intractable diarrhoea which required prolonged parenteral nutrition is reported in a child with acute leukaemia. The enteropathy is likely to have been the consequence of continuing cytotoxic therapy during an episode of acute infective diarrhoea. It is postulated that the inhibition of crypt...

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Bibliographic Details
Published in:European journal of pediatrics 1983-03, Vol.140 (1), p.68-70
Main Authors: Pinkerton, C R, Glasgow, J F, Dempsey, S I
Format: Article
Language:English
Subjects:
Child, Preschool
Diarrhea - chemically induced
Enteritis - complications
Enteritis - microbiology
Female
Humans
Leukemia, Lymphoid - complications
Leukemia, Lymphoid - drug therapy
Methotrexate - adverse effects
Methotrexate - therapeutic use
Virus Diseases - complications
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Summary:Severe intractable diarrhoea which required prolonged parenteral nutrition is reported in a child with acute leukaemia. The enteropathy is likely to have been the consequence of continuing cytotoxic therapy during an episode of acute infective diarrhoea. It is postulated that the inhibition of crypt mitotic activity prevented the rapid recovery of small intestinal mucosa normally seen after viral infection and resulted in persisting small intestinal dysfunction. The inter-relationship between viral and cytoxic-induced enterocyte damage is discussed and the risks of continuing therapy under such conditions is considered.
ISSN:0340-6199
1432-1076
DOI:10.1007/BF00661911