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Presynaptic currents in frog motor endings

Membrane currents were recorded from non-myelinated frog endings by external electrodes. Changes in shape of the signals recorded at varying distances from the myelin end could be explained by assuming a non uniform distribution of Na and K channels along the presynaptic terminal. Specific channel b...

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Published in:	Pflügers Archiv 1984, Vol.400 (1), p.8-13
Main Author:	MALLART, A
Format:	Article
Language:	English
Subjects:	4-Aminopyridine - analogs & derivatives Action Potentials Amifampridine Aminopyridines - pharmacology Animals Biological and medical sciences Electric Conductivity Fundamental and applied biological sciences. Psychology Ion Channels - drug effects Motor Neurons - physiology Nerve Endings - physiology Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Rana esculenta Synapses - drug effects Synapses - physiology Tetraethylammonium Tetraethylammonium Compounds - pharmacology Tetrodotoxin - pharmacology Vertebrates: nervous system and sense organs
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description	Membrane currents were recorded from non-myelinated frog endings by external electrodes. Changes in shape of the signals recorded at varying distances from the myelin end could be explained by assuming a non uniform distribution of Na and K channels along the presynaptic terminal. Specific channel blocking agents revealed that Na channels are present in highest density in the first half of each terminal branch and at almost undetectable levels near the extreme end, while K channels show a more widespread distribution with higher density at medial parts. Suppression of K conductance revealed Ca current which was seen as outward current near the myelin end.
doi_str_mv	10.1007/BF00670529
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Changes in shape of the signals recorded at varying distances from the myelin end could be explained by assuming a non uniform distribution of Na and K channels along the presynaptic terminal. Specific channel blocking agents revealed that Na channels are present in highest density in the first half of each terminal branch and at almost undetectable levels near the extreme end, while K channels show a more widespread distribution with higher density at medial parts. Suppression of K conductance revealed Ca current which was seen as outward current near the myelin end.</description><subject>4-Aminopyridine - analogs & derivatives</subject><subject>Action Potentials</subject><subject>Amifampridine</subject><subject>Aminopyridines - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Electric Conductivity</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Ion Channels - drug effects</topic><topic>Motor Neurons - physiology</topic><topic>Nerve Endings - physiology</topic><topic>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</topic><topic>Rana esculenta</topic><topic>Synapses - drug effects</topic><topic>Synapses - physiology</topic><topic>Tetraethylammonium</topic><topic>Tetraethylammonium Compounds - pharmacology</topic><topic>Tetrodotoxin - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MALLART, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Pflügers Archiv</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MALLART, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presynaptic currents in frog motor endings</atitle><jtitle>Pflügers Archiv</jtitle><addtitle>Pflugers Arch</addtitle><date>1984</date><risdate>1984</risdate><volume>400</volume><issue>1</issue><spage>8</spage><epage>13</epage><pages>8-13</pages><issn>0031-6768</issn><eissn>1432-2013</eissn><coden>PFLABK</coden><abstract>Membrane currents were recorded from non-myelinated frog endings by external electrodes. 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source	Springer LINK Archives
subjects	4-Aminopyridine - analogs & derivatives Action Potentials Amifampridine Aminopyridines - pharmacology Animals Biological and medical sciences Electric Conductivity Fundamental and applied biological sciences. Psychology Ion Channels - drug effects Motor Neurons - physiology Nerve Endings - physiology Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Rana esculenta Synapses - drug effects Synapses - physiology Tetraethylammonium Tetraethylammonium Compounds - pharmacology Tetrodotoxin - pharmacology Vertebrates: nervous system and sense organs
title	Presynaptic currents in frog motor endings
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