Periphery of ethylnitrosourea-induced spinal gliomas in rats with special reference to the vascular structure

The histology and ultrastructure of ten spinal cord gliomas, mainly oligodendrogliomas, induced transplacentally in rat with ethylnitrosourea were studied. The characteristic feature of seven spinal tumours was distinct delineation of neoplastic tissue from the edematous surrounding zone by a ring o...

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Bibliographic Details
Published in:Acta neuropathologica 1987-01, Vol.73 (1), p.92-98
Main Author: KROH, H
Format: Article
Language:English
Subjects:
Animal tumors. Experimental tumors
Animals
Biological and medical sciences
Blood Vessels - ultrastructure
Capillaries - ultrastructure
Ethylnitrosourea
Experimental nervous system tumors
Glioma - blood supply
Glioma - chemically induced
Medical sciences
Microscopy, Electron
Rats
Rats, Inbred Strains
Spinal Cord Neoplasms - blood supply
Spinal Cord Neoplasms - chemically induced
Tumors
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Summary:The histology and ultrastructure of ten spinal cord gliomas, mainly oligodendrogliomas, induced transplacentally in rat with ethylnitrosourea were studied. The characteristic feature of seven spinal tumours was distinct delineation of neoplastic tissue from the edematous surrounding zone by a ring of irregular, proliferating capillaries, among which immature capillary buds prevailed. The alterations were proliferation of endothelium with endothelial overlapping, elongation of interendothelial junctions and enhancement of pinocytotic vesicles on luminal and abluminal surfaces. The basal membranes, besides other changes, were often replaced by some floccular condensations. In the edematous zone the capillary walls were deprived of contact with glial processes. The lack of contact between astrocytic processes and vascular wall may contribute to the persistent immature state of peripheral capillaries.
ISSN:0001-6322
1432-0533
DOI:10.1007/BF00695507