Quantitative morphology. A study of the trophoblast

It is difficult to predict the possible development of a malignant trophoblastic tumor after the evacuation of a hydatidiform mole. In order to help resolve this difficulty, a morphometric study has been carried out. The mean nuclear area of the trophoblast in a group of hydatidiform moles, followed...

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Bibliographic Details
Published in:Virchows Archiv A Pathological Anatomy and Histopathology 1985-01, Vol.406 (3), p.323-331
Main Authors: FRANKE, H. R, ALONS, C. L, CARON, F. J. M, BOOG, M. C, OORT, J, STOCK, J. G
Format: Article
Language:English
Subjects:
Biological and medical sciences
Choriocarcinoma - etiology
Chorionic Villi - pathology
Diseases of mother, fetus and pregnancy
Female
Gynecology. Andrology. Obstetrics
Humans
Hydatidiform Mole - pathology
Medical sciences
Pregnancy
Pregnancy. Fetus. Placenta
Prognosis
Trophoblasts - pathology
Uterine Neoplasms - etiology
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Summary:It is difficult to predict the possible development of a malignant trophoblastic tumor after the evacuation of a hydatidiform mole. In order to help resolve this difficulty, a morphometric study has been carried out. The mean nuclear area of the trophoblast in a group of hydatidiform moles, followed by a trophoblastic malignancy, was found to be statistically significantly larger than that of the trophoblast in a group of hydatidiform moles which were not followed by malignant trophoblastic disease. However, the mean trophoblast/nontrophoblast ratio in villi demonstrated no statistically significant difference between those 2 groups of hydatidiform moles. Therefore it is not advisable to grade hydatidiform moles on the basis of trophoblastic proliferation alone. It is suggested that the trophoblastic lining of hydropic villi in the placental tissue of hydatidiform moles has malignant features already, but these are more pronounced in those hydatidiform moles which are subsequently followed by a choriocarcinoma.
ISSN:0174-7398
1432-2307
DOI:10.1007/BF00704301